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The Science

Recent incredible breakthroughs by international researchers  on how we can slow down, or even reverse, aging demonstrated by better example by infecting mice with reprogramming genes. This study restored eyesight in old mice which disclosed reversing the aging and allowing the cells to survive and grow like a newborn’s. This information led scientists believe that aging is loss of epigenetic rather than genetic information in the form of mutations.


We believe that this bold new theory about aging and increasing lifespan could be reality soon by working with leading scientific community on genetics and longevity.


Hence we are happy to use technology that can foster health care and aging in place. In the near future we may not just be able to feel younger, but actually become younger.


1) Chemistry-oriented synthesis (ChOS) and target deconvolution on the neuroprotective effect of a novel scaffold, oxaza spiroquinone. Arramshetti Venkanna; Kyo Hee Cho; Prema Dhorma Lama; Duddukuri Nandan Kumar; Jung Mi Hah; Hyeung-geun Park; Sun Yeou Kim; Mihyun Kim; European Journal of Medicinal Chemistry, 2018, 163, 453-480.


2) 2,3-Dihydrofurans as Potential Anticancer and Antibacterial agents: Tandem Knoevenagel Michael cyclization for the Synthesis of 2,3- Dihydrofurans by using α-Tosyloxy ketone precursors. Jajula Kashanna, a* Rathod Arvind Kumar,b Ravada Kishore,c Doddukuri Nandan Kumar, D; Chem Biodiverse, 2018, 3, 6859-6864.


3) Synthesis of Novel Thiophene-Chalcone Derivatives as Anticancer- and Apoptosis-Inducing Agents. Nandan Kumar Duddukuri*, Sowjanya Thatikonda, Chandraiah Godugu, Rathod Aravind Kumar, Nandkumar Doijad; ChemSelect, 2018, 3, 6859-6864


4) Catalyst-Free Synthesis of Novel 6-phenyl-6H-chromeno [4, 3-b] quinoline derivatives at RT: Their further structure evaluation leads to potential anti-cancer agents. A. Suman Kumar, R. Aravind Kumar*, E. Pravardhan Reddy, B. Jagan Mohan Reddy, D. Nandan Kumar, A. Khurana, G. Chandraiah, J. S. Yadav. Natural Product Communications. 2017, 12, 1129-1132


5) A simple, concise and stereoselective synthesis of cytotoxic marine metabolite harzialactone A through three different approaches. Duddukuri Nandan Kumar, Cheruku Ravindra Reddy, Biswanath Das*, Synthesis. 3190-3194, 2011.


6) Highly Diastereoselective Synthesis of Substituted Pyrrolidines: Total Synthesis of Bulgecinine. Biswanath Das,* Duddukuri Nandan Kumar, Synlett. 1285-1287, 2011.


7) Stereo controlled the construction of tetrasubstituted tetra hydro furan: Synthesis of 2,5-anhydro- D-glucitol. Biswanath Das*, Duddukuri Nandan Kumar, Tetrahedron Lett. 51,6011-6013, 2009. (This paper has been included: Organic Chemistry Portal, Organic chemistry highlights, April 11, 2011).


8) A simple advantageous synthesis of 5-substituted 1H-tetrazoles. Biswanath Das,*Cheruku Ravindra Reddy, Duddukuri Nandan Kumar, Martha Krishnaiah and Ravirala Narender. Synlett. 3, 391, 2010.


9) An efficient synthesis of N-tosylamino alkyl naphthols by nucleophilic addition of 2-naphthol with N-tosylimines using boron trifluoride etherate as a catalyst. Biswanath Das,* Cheruku Ravindra Reddy, Chava Sindhu, Duddukuri Nandan Kumar, Helv. Chem. Acta. 94, 2, 289-292, 2011.


10) Stereoselective total synthesis of a potent natural antifungal compound (6S)-5, 6, dihydro-6-[(2R)-2-hydroxy-6-phenyl hexyl]-2H-pyran-2-one†of phytotoxic 10-membered lactone. B. Das, K. Laxminarayana, M. Krishnaiah, Duddukuri Nandan Kumar, Bioorganic & Medicinal Chemistry Letters. 19, 6396-6398, 2009.


11) A Stereoselective Total Synthesis of Verbalactone. B. Das, K. Laxminarayana, M. Krishnaiah, Duddukuri Nandan Kumar. Helvetica. Chim. Acta. 92, 1840–1844, 2009.

12) Stereoselective total synthesis of dodoneine. Biswanath Das, Kanaparthy Suneel, Gandham Satyalakshmi, and Duddukuri Nandan Kumar. Tetrahedron Asymmetry. 20,1536-1540, 2009.


13) Simple and efficient metal-free hydroarylation and hydroalkylation using Amberlyst - 15. B. Das, M. Krishnaiah, K. Laxminarayana, K. Damodhar, D. N. Kumar, Chemistry Letters. 38, 1, 42, 2009.


14) A remarkably simple N-formylation of anilines using polyethylene glycol. B. Das, M.Krishnaiah,

P. Balasubramanyam, B. Veeranjaneyulu, and D. Nandan Kumar, Tetrahedron Lett. 49, 2225, 2008.


15) Silica supported phosphomolybdic acid: An efficient heterogeneous catalyst for Friedlander synthesis of quinolines. B. Das, M. Krishnaiah, K. Laxminarayana, D. N. Kumar, Chemical&Pharmaceutical Bulletin, 56, 7, 1049, 2008.


16) Silica-supported Phosphomolybdic Acid-catalyzed Efficient synthesis of 1,8-Dioxooctahydroxanthene and Tetrahydrochromene Derivatives. B. Das, M. Krishnaiah, K.Laxminarayana, D. N. Kumar, Chemistry Letters. 37, 9, 1000, 2008.


17) Perchloric acid-silica (HClO4 SiO2)-catalyzed synthesis of 14-alkyl- or 14-aryl-14Hdibenzo[

a, j]xanthenes and N-[(2-hydroxynaphthalen-1-yl) methyl] amides. B. Das, D. N. Kumar, K. Laxminarayana and B. Ravikanth, Helv. Chim. Acta. 90, 1330, 2007.


18) A rapid regioselective ring-opening of aziridines with potassium thiocyanate using ammonium-12-molybdophosphate. Biswanath Das, V. Saidi Reddy, R. Ramu, D. Nandan Kumar, Catalysis Communications. 7, 12, 997-999, 2006.

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